{"id":306,"date":"2022-04-10T13:41:17","date_gmt":"2022-04-10T13:41:17","guid":{"rendered":"https:\/\/lab.flygen.org\/?p=306"},"modified":"2022-04-10T13:42:00","modified_gmt":"2022-04-10T13:42:00","slug":"new-preprint-on-neuronal-branching-and-synapse-formation","status":"publish","type":"post","link":"https:\/\/lab.flygen.org\/?p=306","title":{"rendered":"New preprint on neuronal branching and synapse formation"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\" id=\"page-title\"><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.04.06.486606v1\" target=\"_blank\" rel=\"noreferrer noopener\">A critical developmental interval of coupling axon branching to synaptic degradation during neural circuit formation<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Suchetana B. Dutta, Gerit Arne Linneweber, Maheva Andriatsilavo, Peter Robin Hiesinger, Bassem A Hassan<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ABSTRACT<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"p-2\">The emergence of neuronal wiring specificity requires stabilization of dynamic axonal branches at sites of selective synapse formation. Models that explain how axonal branching is coupled to synaptogenesis postulate molecular regulators acting in a spatiotemporally restricted fashion. We report that Epidermal Growth Factor Receptor (EGFR) activity is required in presynaptic axonal branches during two distinct temporal intervals to regulate circuit wiring in the developing <em>Drosophila<\/em> visual system. EGFR is required early to regulate primary axonal branching and independently again later to prevent autophagic degradation of the synaptic active zone protein Bruchpilot (Brp). The protection of synaptic material during this later interval of wiring ensures the stabilization of terminal branches, circuit connectivity and appropriate visual behavior. Phenotypes of EGFR inactivation were rescued by increasing Brp levels or downregulating autophagic genes. We identify a temporally restricted molecular mechanism required for coupling axonal branching and synaptic stabilization that contributes to the emergence of neuronal wiring specificity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">doi: https:\/\/doi.org\/10.1101\/2022.04.06.486606<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A critical developmental interval of coupling axon branching to synaptic degradation during neural circuit formation Suchetana B. Dutta, Gerit Arne Linneweber, Maheva Andriatsilavo, Peter Robin Hiesinger, Bassem A Hassan ABSTRACT&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-306","post","type-post","status-publish","format-standard","hentry","category-publications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New preprint on neuronal branching and synapse formation - Hiesinger Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.flygen.org\/?p=306\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New preprint on neuronal branching and synapse formation - Hiesinger Lab\" \/>\n<meta property=\"og:description\" content=\"A critical developmental interval of coupling axon branching to synaptic degradation during neural circuit formation Suchetana B. 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