{"id":26,"date":"2021-11-26T11:44:58","date_gmt":"2021-11-26T11:44:58","guid":{"rendered":"https:\/\/lab.flygen.org\/?page_id=26"},"modified":"2026-03-13T15:29:48","modified_gmt":"2026-03-13T15:29:48","slug":"publications","status":"publish","type":"page","link":"https:\/\/lab.flygen.org\/?page_id=26","title":{"rendered":"Publications"},"content":{"rendered":"\n

All links open original lab publication PDF files in a new tab. For more info on the book ‘The Self-Assembling Brain’ visit selfassemblingbrain.com<\/a>.<\/p>\n\n\n\n

2026<\/h2>\n\n\n\n

Kehribar M, Wit CB, Krasikova K, Agi E, Reifenstein ET, Wolterhoff N, Wriedt LQ, von Kleist M, and Hiesinger PR<\/strong> (2026). Selective adhesion preserves eye patterning as axonal retinotopy in the Drosophila brain (2026). Current Biology<\/em>, <\/strong>in press<\/em>, pre-pub online Feb 3, 2026<\/a>, doi: 10.1016\/j.cub.2026.01.007
see also Cell Press Video Abstract on YouTube<\/a> and the Dispatch on this article <\/a>in Curr Biol<\/em><\/strong>. by I.Salecker<\/p>\n\n\n\n

Brence B, Brummer J, Derchsken VJ, \u00d6zel MN, Kulkarni A, Wolterhoff N, Prohaska S, Hiesinger PR<\/strong>, Baum D (2026). Semi-automatic Geometrical Reconstruction and Analysis of Filopodia Dynamics in 4D Two-Photon Microscopy Images, BMC Bioinformatics<\/em><\/strong>, in press<\/em>. doi: 10.1186\/s12859-026-06385-4<\/p>\n\n\n\n

Fuchs, J., Cherkaoui, K., and Hiesinger, PR <\/strong>(2026). Adherens junctions balance stability and motility: from cell morphogenesis to neural tissue patterning. Biol. Chem.<\/em><\/strong> in press<\/em><\/p>\n\n\n\n

2025<\/h2>\n\n\n\n

Ahmed M and Hiesinger PR<\/strong> (2025). The mind of a predatory worm. Science<\/em><\/strong>, 389(6759):452-453..<\/a><\/p>\n\n\n\n

Andriatsilavo M, Barata C, Reifenstein E, Dumoulin A, Tao Griffin T, Dutta SB, Stoeckli ET, von Kleist M, Hiesinger PR<\/strong>, Hassan BA. (2025) Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster. Nat Neurosci<\/em>.<\/strong> doi: 10.1038\/s41593-025-01937-y. <\/a><\/p>\n\n\n\n

Karpova A, Hiesinger PR<\/strong>, Kuijpers M, Albrecht A, Kirstein J, Andres-Alonso M, Biermeier A, Eickholt BJ, Mikhaylova M, Maglione M, Montenegro-Venegas C, Sigrist SJ, Gundelfinger ED, Haucke V, Kreutz MR. (2025) Neuronal autophagy in the control of synapse function. Neuron<\/strong> <\/em>113(7):974-990. doi: 10.1016\/j.neuron.2025.01.019. <\/a><\/p>\n\n\n\n

2024<\/h2>\n\n\n\n

Agi, E.*, Reifenstein, E.T.*, Wit, C., Schneider, T., Kauer, M., Kehribar, M., Kulkarni, A., von Kleist, M.*, and Hiesinger, P.R.* <\/strong>(2024). Axonal Self-Sorting Without Target Guidance in Drosophila Visual Map Formation. Science<\/em><\/strong>, 2024 Mar 8;383(6687):1084-1092.<\/a><\/p>\n\n\n\n

Wolterhoff, N. and Hiesinger, P.R. <\/strong>(2024). Synaptic Promiscuity in Brain Development. Curr Biol<\/em>.<\/strong> 2024 Feb 5;34(3):R102-R116.<\/a><\/p>\n\n\n\n

2023<\/h2>\n\n\n\n

Fuchs, J. and Hiesinger, P.R. <\/strong>(2023). Brain wiring: Love the one you’re with. Curr Biol.<\/em> <\/strong>(Dispatch). 33(13):R727-R729<\/em><\/a><\/p>\n\n\n\n

Daumann, I.-M. and Hiesinger, P.R. <\/strong>(2023). Lipid rafts, rab GTPases and a late endosomal checkpoint for plasma membrane recycling. Proc. Natl. Acad. Sci.<\/strong> USA<\/em>, 120(14):e2302320120.<\/em><\/a><\/p>\n\n\n\n

Hassan B.A. and Hiesinger, P.R. <\/strong>(2023). Autophagy in Synapse Formation and Brain Wiring. Autophagy<\/em><\/strong>. 19(10):2814-2816.<\/em><\/a><\/p>\n\n\n\n

Kehribar, M. and Hiesinger, P.R. <\/strong>(2023). Turnover of Synaptic Adhesion Molecules. Mol. Cell. Neurosci<\/em>. <\/strong>124:103816.<\/em><\/a><\/p>\n\n\n\n

Dutta, S.B., Linneweber, G.A., Andriatsilavo, M., Hiesinger, P.R<\/strong>.*, and Hassan, B.A.* (2023). EGFR-dependent suppression of synaptic autophagy is required for neuronal circuit development. Curr. Biol<\/em>.,<\/strong> 33, 1-16. * co-corresponding authors.<\/a><\/p>\n\n\n\n

2022<\/h2>\n\n\n\n

Wit, C. and Hiesinger, P.R.<\/strong> (2022). Neuronal Filopodia: From Stochastic Dynamics to Robustness of Brain Morphogenesis. Sem. Cell Dev. Biol<\/em>. <\/strong>https:\/\/doi.org\/10.1016\/j.semcdb.2022.03.038.<\/a><\/p>\n\n\n\n

2021<\/h2>\n\n\n\n

Kiral, F.R., Dutta, S.B., Linneweber, G.A., Poppa, C., Duch, C., von KLeist, M., Hassan, B.A., and Hiesinger, P.R.<\/strong> (2021). Brain Connectivity inversely scales with developmental temperature in Drosophila<\/em>, Cell Rep.<\/em><\/strong> 37(12):110145<\/em>.<\/a><\/p>\n\n\n\n

Kohrs, F.E*, Daumann, I.M.*, Pavlovi\u0107, B., Jin, E.J., Lin, S.C. Port, F., Kiral, F.R., Wolfenberg, H., Mathejczyk, T.F., Linneweber, G.A., Chan, C.C., Boutros, M., Hiesinger, P.R.<\/strong> (2021) Systematic functional analysis of Rab GTPases reveals limits of neuronal robustness to environmental challenges in flies eLife<\/em><\/strong> 10:e59594<\/em> * co-first authors<\/a><\/p>\n\n\n\n

Hiesinger, P.R.<\/strong> (2021). Brain Wiring with Composite Instructions. BioEssays<\/strong> e2000166<\/em>.<\/a><\/p>\n\n\n\n

2020<\/h2>\n\n\n\n

Kessissoglou I.A., Langui D., Hasan A., Maral M., Dutta S.B., Hiesinger P.R.<\/strong>, Hassan B.A. (2020). The Drosophila amyloid precursor protein homologue mediates neuronal survival and neuroglial interactions. PloS Biology<\/em><\/strong>, 18(12):e3000703.<\/a><\/p>\n\n\n\n

Kiral F.R., Linneweber G.A., Mathejczyk T.F., Georgiev S.V., Wernet M.F., Hassan B.A., von Kleist M., Hiesinger P.R.<\/strong> (2020). Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring, preprint at BioRxiv, Nature Communications<\/em><\/strong>, 12;11(1):1325.<\/em><\/a><\/p>\n\n\n\n

Linneweber, G.A.,Andriatsilavo, M.,Dutta, S.,Bengochea, M.,Hellbruegge, L., Liu, G.,Ejsmont, R.K.,Straw, A.D., Wernet, M.F., Hiesinger, P.R.<\/strong>, Hassan, B.A. (2020). A neurodevelopmental origin of behavioral individuality in the Drosophila visual system. Science<\/em><\/strong>, 367(6482):1112-1119.<\/a><\/p>\n\n\n\n

Agi, E., Kulkarni, A., and Hiesinger, P.R.<\/strong> (2020). Neuronal strategies for meeting the right partner during brain wiring. Curr. Opin. Neurobiol<\/em><\/strong>, 63:1-8.<\/a><\/p>\n\n\n\n

2019<\/h2>\n\n\n\n

Ozel, M.N.*, Kulkarni, A.*, Hasan, A.*, Brummer, J., Moldenhauer, M., Daumann, I.M., Wolfenberg, H., Dercksen, V.J., Kiral, F.R., Weiser, M., Prohaska, S., von KLeinst, M.*, Hiesinger, P.R.*<\/strong> Serial synapse formation through filopodial competition for synaptic seeding factors, Developmental Cell<\/strong> 50<\/em>(4):447-461.e8.<\/a><\/p>\n\n\n\n

2018<\/h2>\n\n\n\n

Hiesinger, P.R.<\/strong> and Hassan, B.A. (2018). The Evolution of Variability and Robustness in Neural Development. Trends in Neuroscience<\/strong> 41(9):577-586<\/em><\/a><\/p>\n\n\n\n

Jin E.J., Kiral, F.K., \u00d6zel, M.N., Burchardt, L.S., Osterland, M., Epstein, D., Wolfenberg, H., Prohaska, S., and Hiesinger, P.R.<\/strong> (2018). Live Observation of Two Parallel Membrane Degradation Pathways at Axon Terminals. Curr. Biol<\/strong> <\/em>28(7):1027-1038.e4<\/a><\/p>\n\n\n\n

Kiral, F.K., Kohrs, F., Jin, E.J. and Hiesinger, P.R.<\/strong> (2018) Rab GTPases and Membrane Trafficking in Neurodegeneration. Curr Biol.<\/strong> 28(8):R471-R486<\/em><\/a><\/p>\n\n\n\n

2017<\/h2>\n\n\n\n

Jin E.J., Kiral, F.R. and Hiesinger, P.R.<\/strong> (2017) The Where, What and When of Membrane Protein Degradation in Neurons. Dev. Neurobiol.<\/strong> doi: 10.1002\/dneu.22534<\/a><\/p>\n\n\n\n

\u00d6zel, M.N. and Hiesinger, P.R.<\/strong> (2017) Live Imaging of Connectivity in Developing Neural Circuits in Drosophila. In: Decoding Neural Circuit Structure and Function<\/em>, Springer 2017, p.149-167<\/a><\/p>\n\n\n\n

Kolodkin, A.L. and Hiesinger, P.R.<\/strong> (2017) Wiring visual systems: common and divergent mechanisms and principles. Curr. Opin. Neurobiol<\/em>.<\/strong> 42:128-135<\/a><\/p>\n\n\n\n

2016<\/h2>\n\n\n\n

Klionsky et al., (2016)Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Autophagy<\/strong> <\/em>12(1), 1\u2013222<\/p>\n\n\n\n

Garaulet, D.L., Sun, K., Li, W., Wen, J., Panzarino, A.M., O’Neil, J.L., Hiesinger, P.R.<\/strong>, Young, M.W., and Lai, E.C. (2016) miR-124 Regulates Diverse Aspects of Rhythmic Behavior in Drosophila. J. Neurosci<\/em>.<\/strong> 36(12):3414 \u20133421<\/p>\n\n\n\n

Hiesinger, P.R. and Hassan, B.A. (2016) The Tightrope of Mentorship Cell<\/strong> <\/em>Leading Edge: Voices, 164:1093<\/a><\/p>\n\n\n\n

2015<\/h2>\n\n\n\n

Ozel, M.N., Langen, M., Hassan, B.A. and Hiesinger, P.R.<\/strong> (2015) Filopodial Dynamics and Growth Cone Stabilization in Drosophila Visual Circuit Development. eLife<\/em><\/strong>, e10721<\/em><\/a><\/p>\n\n\n\n

Hassan, B.A. and Hiesinger, P.R.<\/strong> (2015) Beyond Molecular Codes: Simple Rules to Wire Complex Brain. Cell<\/em><\/strong>, 163(2):285-291<\/em> | [PDF]<\/a><\/p>\n\n\n\n

Langen, M.*, Agi, E.*, Altschuler, D., Wu, L.*, Altschuler, S.*, and Hiesinger, P.R.<\/strong>* (2015) The Developmental Rules of Neural Superposition. Cell<\/em><\/strong>, 162(1):120-33<\/em> | [PDF] <\/a>| [Suppl. Materials PDF]<\/a>
Highlighted in: Wernet, M.F. and Desplan, C. (2015) Brain Wiring in the Fourth Dimension | Cell [PDF]<\/a><\/em><\/p>\n\n\n\n

2014<\/h2>\n\n\n\n

Agi, E., Langen, M., Altschuler, S., Wu, L., Zimmermann, T., and Hiesinger, P.R.<\/strong> (2014) The Evolution and Development of Neural Superposition, J. Neurogenetics<\/em><\/strong>, 28(3-4):216-32.<\/em> | [PDF]<\/a><\/p>\n\n\n\n

Wang, D., Epstein, D., Khalaf, O., Srinivasan, S., Williamson, W.R., Fayyazuddin, A., Quiocho, F.A., and Hiesinger, P.R.<\/strong> (2014)<\/em>. Calcium\/Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1. J. Cell. Biol<\/em>.<\/strong> 205(1):21-31<\/em>. | [PDF]<\/a> | [Suppl. Mat. PDF]<\/a>
  Highlighted in: Vavassori and Mayer (2014) J.Cell Biol. 205(1):7-99<\/em> | [PDF]<\/a><\/p>\n\n\n\n

Zschatzsch, M., Oliva, C., Langen, M., De Geest, N., Ozel, M.N., Williamson , W.R., Lemon, W., Soldano, A., Munck, S., Hiesinger P.R.<\/strong>, Sanchez-Soriano, N., Hassan, B. (2014)<\/em> Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor Signaling. eLife<\/em><\/strong>, 3:e01699.<\/em> | [PDF]<\/a><\/p>\n\n\n\n

2013<\/h2>\n\n\n\n

Cherry, S., Jin, E.J., Ozel, M.N., Lu, Z., Agi, E., Wang, D., Meinertzhagen, I.A., Chan, C.-C., and Hiesinger, P.R.<\/strong> 2013<\/em>. Charcot-Maire-Tooth 2B mutations in rab7 cause dosage-dependent neurodegeneration due to partial loss of function. eLife<\/em><\/strong>, 2(0):e01064<\/em> | [PDF]<\/a>
  Highlighted in: Sadandappa, M.K. and Ramaswami, M. (2013) eLife e01820<\/em> | [PDF]<\/a><\/p>\n\n\n\n

Wang, D. and Hiesinger, P.R.<\/strong> (2013)<\/em>. The vesicular ATPase: a missing link between acidification and exocytosis. J. Cell. Biol<\/em>.<\/strong>, 203(2):171-3<\/em> | [PDF]<\/a><\/p>\n\n\n\n

Bezprozvanny, I., and Hiesinger, P.R.<\/strong> (2013)<\/em>. The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration. Mol. Neurodegeneration<\/em><\/strong>, 8:23. | [PDF]<\/a><\/p>\n\n\n\n

Carrerira-Rosario, A., Scoggin, S., Shalaby, N.A., Williams, N.D., Hiesinger, P.R.<\/strong> and Buszczak, M. (2013)<\/em>. Recombineering Homologous Recombination Constructs in Drosophila. J. Vis. Exp<\/em>.<\/strong> | [PDF]<\/a> | <\/a><\/p>\n\n\n\n

Wang, D., Chan, C.C., Cherry, S. and Hiesinger, P.R.<\/strong> (2013)<\/em>. Membrane trafficking in Neuronal Maintenance and Degeneration. Cell. Mol. Life Sci.<\/strong>, 70(16):2919-34<\/em>. | [PDF]<\/a><\/p>\n\n\n\n

2012<\/h2>\n\n\n\n

Williamson, W.R., Chan, C.C., and Hiesinger, P.R.<\/strong> (2012)<\/em>. Subcellular Resolution Imaging in Neural Circuits. Bookchapter in:<\/em> The Making and Un-Making of Neuronal Circuits, Bassem Hassan, Editor, Humana Press, p.61-90<\/em> | [PDF]<\/a><\/p>\n\n\n\n

Jin, E.J., Chan, C.C., Agi, E., Cherry, S., Hanacik, E., Buszczak, M., and Hiesinger, P.R.<\/strong> (2012)<\/em>. Similarities of Drosophila rab GTPases Based on Expression Profiling: Completion and Analysis of the rab-Gal4 Kit. PLoS One<\/em><\/strong>, 7(7):e40912<\/em> | [PDF]<\/a><\/p>\n\n\n\n

Coen, K. Flannagan, R.S., Carraro-Lacroix, L.R., Wang, D., Vermeire, W., Michiels, C. Munck, S., Sugita, S., Hiesinger, P.R.<\/strong> Grinstein, S., Annaert, W. (2012)<\/em> Endo-lysosomal dysfunction in PSEN-deficient cells is caused by defects in lysosomal calcium homeostasis and not by defective proton pump function. J. Cell Biol<\/em>.<\/strong>, 198(1):23-35<\/em> | [PDF]<\/a><\/p>\n\n\n\n

Wang, D., and Hiesinger, P.R.<\/strong> (2012)<\/em>. Autophagy, Neuron-Specific Degradation and Neurodegeneration. Autophagy<\/em><\/strong>, 8(4):711-3<\/em> | [PDF]<\/a><\/p>\n\n\n\n

Haberman, A.S., Williamson, W.R., Epstein, D., Wang, D., Rina, S., Meinertzhagen, I.A. and Hiesinger, P.R.<\/strong> (2012)<\/em>. The synaptic vesicle SNARE neuronal Synaptobrevin promotes endolysosomal degradation and prevents neurodegeneration in Drosophila. J. Cell. Biol.<\/em><\/strong>, 196<\/em>, 261-276. | [PDF]<\/a> | [PDF]<\/a> | [Cover]<\/a><\/p>\n\n\n\n

Chan, C.C., Scoggin, S., Hiesinger, P.R.*<\/strong> and Buszczak, M.* (2012)<\/em>. Combining recombineering and ends-out homologous recombination to systematically characterize Drosophila gene families: rab GTPases as a case study. Comm. Integr. Biol<\/em>.<\/strong>, 5(2):179-83<\/em> * co-corresponding authors | [PDF]<\/a><\/p>\n\n\n\n

2011<\/h2>\n\n\n\n

Chan, C.C., Scoggin, S., Wang, D., Cherry, S., Dembo, T., Greenberg, B., Jin, E.J., Kuey, C., Lopez, A., Mehta, S.Q., Perkins, T.J., Brankatschk, M., Rothenfluh, A., Buszczak, M.*, and Hiesinger, P.R.* (2011)<\/em>. Systematic Discovery of Rab GTPases with Synaptic Functions in Drosophila. Current Biology<\/strong>, 21(20):1704-15<\/em>. * co-corresponding authors | [PDF]<\/a> | [Supplemental Materials PDF]<\/a>
  Highlighted in: Harris, K.P. and Littleton, J.T. (2011) Vesicle Trafficking: A Rab Family Profile. Curr. Biol.<\/strong> 21(20):841-843. | [Dispatch PDF]<\/a><\/em><\/p>\n\n\n\n

Chan, C.C., Epstein, D., and Hiesinger, P.R.<\/strong> (2011)<\/em>. Intracellular Trafficking in Drosophila Visual System Development: A Basis for Pattern Formation through Simple Mechanisms. Dev. Neurobiol<\/em>.<\/strong>, 71(12):1227-45<\/em>. | [PDF]<\/a><\/p>\n\n\n\n

Smibert, P., Bejarano, F., Wang, D., Garaulet, D.L., Yang, J.-S., Martin, R., Bortolamiol-Becet, D., Robine, N., Hiesinger, P.R.<\/strong> and Lai, E.C.. (2011)<\/em> A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs. RNA<\/em><\/strong>, 17(11):1997-2010<\/em> | [PDF]<\/a><\/p>\n\n\n\n

2010<\/h2>\n\n\n\n

Williamson, W.R., Yang, T., Terman, J.R., and Hiesinger, P.R.<\/strong> (2010)<\/em>. Guidance Receptor Degradation is Required for Neuronal Connectivity in the Drosophila Nervous System. PLoS Biology<\/em><\/strong>, 8(12):e1000553<\/em> [PDF]<\/a> | [Cover]<\/a><\/p>\n\n\n\n

Williamson, W.R. and Hiesinger, P.R.<\/strong> (2010)<\/em>. On the role of v-ATPase V0a1-dependent degradation in Alzheimer Disease. Comm. Int. Biol<\/em>.<\/strong> (in press)<\/em> [PDF]<\/a><\/p>\n\n\n\n

Williamson, W.R., Wang, D., Haberman, A.S. and Hiesinger, P.R.<\/strong> (2010)<\/em>. A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila<\/em> photoreceptors. J. Cell. Biol.<\/em><\/strong>, 189:<\/em> 885-99. [PDF]<\/a> | [Cover]<\/a>
  Highlighted in: In Focus Article ‘The acid test of v-ATPase function’ by Ben Short, J. Cell. Biol.<\/strong> 189:773. <\/em>[PDF]<\/a><\/p>\n\n\n\n

Williamson, W.R. and Hiesinger, P.R.<\/strong> (2010)<\/em>. Preparation of Developing and Adult Drosophila Brains and Retinae for Live Imaging. J. Vis. Exp<\/em><\/strong>., 37.<\/em> doi:10.3791\/1936. [PDF]<\/a> | <\/a><\/p>\n\n\n\n

2009<\/h2>\n\n\n\n

Hiesinger, P.R.<\/strong> and Meinertzhagen, I.A. (2009)<\/em> Visual System Development: Invertebrates. in: Squire LR (ed.) Encyclopedia of Neuroscience<\/em><\/strong>, volume 10, pp. 313-322. Oxford: Academic Press, Elsevier. [PDF]<\/a><\/p>\n\n\n\n

2008<\/h2>\n\n\n\n

Williamson, W.R. and Hiesinger, P.R.<\/strong> (2008)<\/em>. Synaptic Patterning by Morphogen Signaling. Science Signaling<\/em><\/strong>, 1(18):pe20. [PDF]<\/a><\/p>\n\n\n\n

Zhai, R.G., Zhang, F., Hiesinger, P.R.<\/strong>, Cao, Y., Haeuter, C.M., and Bellen, H.J. (2008)<\/em>. NAD Synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature<\/em><\/strong>, 452:887-91. [PDF]<\/a><\/p>\n\n\n\n

Zhang, W., Wang, D., Volk, E., Bellen, H.J., Hiesinger, P.R.*<\/strong>, Quiocho, F.A.* (2008)<\/em> * co-corresponding authors<\/em>
v-ATPase V0 sector subunit a1 in neurons is a target of calmodulin. Journal of Biological Chemistry<\/em><\/strong>, in press. [ PDF ]<\/a><\/p>\n\n\n\n

Fischbach, K.F. and Hiesinger, P.R.<\/strong> (2007)<\/em> Optic Lobe Development, in Brain Development of Drosophia, Ed. G. Technau<\/strong>, Landes Biosciences.   [ Pre-print PDF ]<\/a> | [ Publisher link ]<\/a><\/p>\n\n\n\n

2007<\/h2>\n\n\n\n

Zhang, J., Schulze, K.L., Hiesinger, P.R.<\/strong>, Suyama, K., Wang, S., Fish, M., Acar, M., Hoskins, R.A., Bellen, H.J., and Scott, M.P. (2007)<\/em> 31 Flavors of Drosophila<\/em> Rab Proteins. Genetics<\/strong> <\/em>176:1307-1322.   [ PDF ]<\/a> | [ PDF suppl ]<\/a><\/p>\n\n\n\n

2006<\/h2>\n\n\n\n

Zhai, R.G., Cao, Y., Hiesinger, P.R.<\/strong>, Mehta, S.Q., Schulze, K.L., Verstreken, P., Zhou, Y. and Bellen, H.J. (2006)<\/em>. Drosophila<\/em> NMNAT Maintains Neural Integrity Independent of its NAD Synthesis Activity. PloS Biology<\/strong> <\/em>4(12):e416. [PDF]<\/a><\/p>\n\n\n\n

Hiesinger, P.R.* #<\/sup><\/strong>, Zhai, R.G.*, Zhou, Y., Koh, T.-W., Mehta, S.Q., Verstreken, P., Schulze, K.L., Cao, Y., Fischbach, K.-F., Meinertzhagen, I.A., and Bellen, H.J.#<\/sup><\/strong>, (2006)<\/em>. Activity-independent prespecification of synaptic partners in the visual map of Drosophila<\/em> Curr. Biol<\/em>.<\/strong>, 16, <\/em>1835-43 *co-first authors, #<\/sup> corresponding authors<\/em> [PDF]<\/a> | [PDF suppl]<\/a><\/p>\n\n\n\n

Fayyazuddin, A., Zaheer, M., Hiesinger, P.R.<\/strong>, and Bellen, H.J. (2006<\/em>) giant fiber A<\/em> (gfA<\/em>) encodes a nicotinic acetylcholine receptor that mediates synaptic transmission in the giant fiber circuit of Drosophila<\/em>.PloS Biology<\/strong> 4<\/em>(3):e63. [PDF]<\/a><\/p>\n\n\n\n

2005<\/h2>\n\n\n\n

Hiesinger, P.R. <\/strong>and Hassan, B.A. (2005)<\/em>. Genetics in the Age of Systems Biology. Cell<\/em><\/strong>, 123, 1173-4. [PDF]<\/a><\/p>\n\n\n\n

Hiesinger, P.R.<\/strong>, Fayyazuddin, A., Mehta, S.Q., Rosenmund, T., Schulze, K.L., Zhai, R.G., Verstreken, P., Cao, Y., Zhou, Y., Kunz, J., and Bellen, H.J. ( 2005<\/em>). The v-ATPase V0<\/sub> subunit is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell<\/strong> 121<\/em>, 607-620. Cover article<\/em>. [PDF]<\/a> | [PDF suppl]<\/a> | [Cover]<\/a>
 Preview in Cell 121, 496-497. Bajjalieh, S.A new view of an old pore.<\/em><\/p>\n\n\n\n

Mehta, S.Q.*<\/strong>, Hiesinger, P.R.*<\/strong>, Beronja, S., Zhai, R.G., Schulze, K.L., Verstreken, P., Cao, Y., Zhou, Y. Tepass, U., Crair, M.C., and Bellen, H.J. (2005<\/em>). *co-first authors<\/em> Mutations in Drosophila sec15<\/em> reveal a function in neuronal targeting for a subset of exocyst components. Neuron<\/strong> 46, <\/em>219-232. [PDF]<\/a>
 Preview in Neuron 46, 164-166. Clandinin, T.R. Surprising twists to exocyst function.<\/em><\/p>\n\n\n\n

2004<\/h2>\n\n\n\n

Meinertzhagen I.A. and Hiesinger, P.R.<\/strong> (2004)<\/em>. Visual system development, invertebrates. Elsevier\u2019s Encyclopedia of Neuroscience<\/strong> [link]<\/a><\/p>\n\n\n\n

Hiesinger, P.R.<\/strong> and Bellen H.J.(2004)<\/em>. Flying in the face of total disruption. Nature Genetics<\/strong> 36, 211-212.<\/em> [PDF]<\/a><\/p>\n\n\n\n

Bellen, H.J., Levis, R.W., Liao, G., He, Y., Carlson, J.W., Tsang, G., Evans-Holm, M., Hiesinger, P.R.<\/strong>, Schulze, K.L., Rubin, G.M., Hoskins, R.A., and Spradling, A.C. (2004)<\/em>. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila<\/em> genes. Genetics<\/strong> 167<\/em>, 761-781. [PDF]<\/a><\/p>\n\n\n\n

2003<\/h2>\n\n\n\n

Zhai, R.G.*<\/strong>, Hiesinger, P.R.*<\/strong>, Koh, T.-W., Verstreken, P., Schulze, K.L., Cao, Y., Jafar-Nejad, H., Norga, K.K., Pan, H., Bayat, V., Greenbaum, M.P., and Bellen, H.J. (2003)<\/em>. Mapping Drosophila<\/em> mutations with molecularly defined P<\/em> element insertions. Proc. Natl. Acad. Sci. USA<\/strong> 100<\/em>, 10860-10865. *co-first authors<\/em> [PDF]<\/a>
Featured Highlight in Nature Reviews Genetics 4, 849. Casci, T. I can name it in three…<\/em><\/p>\n\n\n\n

Verstreken, P., Koh, T.-W., Schulze, K.L., Zhai, R.G., Hiesinger, P.R.<\/strong>, Zhou, Y., Mehta, S.Q., Cao, Y., Roos, J., and Bellen, H.J. (2003)<\/em>. Synaptojanin is recruited by Endophilin to promote synaptic vesicle uncoating. Neuron<\/strong> 40<\/em>, 733-748. [PDF]<\/a>
  Preview in Neuron 40, 665-667. Song, W. and Zinsmaier, K.E. Endophilin and Synaptojanin hook up to promote synaptic vesicle endocytosis.<\/em><\/p>\n\n\n\n

Fabian-Fine, R., Verstreken, P., Hiesinger, P.R.<\/strong>, Horne, J.A., Kostyleva, R., Zhou, Y., Bellen, H.J., and Meinertzhagen, I.A. (2003)<\/em>. Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals. J. Neurosc<\/em>i.<\/strong> 23<\/em>, 10732-10744. Cover article<\/em>. [PDF]<\/a> | [Cover]<\/a><\/p>\n\n\n\n

2002<\/h2>\n\n\n\n

Morales, J., Hiesinger, P.R.<\/strong>, Schroeder, A.J., Kume, K., Verstreken, P., Jackson, F.R., Nelson, D.L., and Hassan, B.A. (2002)<\/em>. Drosophila Fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron<\/strong> 34<\/em>, 961-972. [PDF]<\/a><\/p>\n\n\n\n

Pennetta, G., Hiesinger, P.R.<\/strong>, Fabian-Fine, R., Meinertzhagen, I.A., and Bellen H.J. (2002)<\/em>. Drosophila<\/em> VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner. Neuron<\/strong> 35<\/em>, 291-306. Cover article<\/em>. [PDF]<\/a> | [Cover]<\/a><\/p>\n\n\n\n

Kango-Singh, M., Nolo, R., Tao, C., Verstreken, P., Hiesinger, P.R.<\/strong>, Bellen, H.J., and Halder, G. (2002)<\/em>. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila<\/em>. Development<\/strong> 129<\/em>, 5719-5730. Cover article<\/em>. [PDF]<\/a> | [Cover]<\/a><\/p>\n\n\n\n

2001<\/h2>\n\n\n\n

Hiesinger, P.R.*<\/strong> , Scholz, M.*<\/strong>, Meinertzhagen, I.A., Fischbach, K.-F., and Obermayer, K. (2001). Visualization of synaptic markers in the optic lobe neuropils of Drosophila using a new constrained deconvolution method. J. Comp. Neurol<\/strong><\/em>.<\/strong> 429<\/em>, 277-288. *co-first and corresponding authors<\/em>. [PDF]<\/a><\/p>\n\n\n\n

2000<\/h2>\n\n\n\n

Hiesinger, P.R.<\/strong> (2000)<\/em>. The evolution of the millenium bug. Riv. Biol.\/Biology Forum<\/em><\/strong> 93<\/em>, 169-174.<\/p>\n\n\n\n

1999<\/h2>\n\n\n\n

Hiesinger, P.R.<\/strong>, Reiter, C., Schau, H., and Fischbach, K.-F. (1999)<\/em>. Neuropil pattern formation and regulation of cell adhesion molecules in Drosophila<\/em> optic lobe development depend on synaptobrevin. J. Neurosci<\/em>.<\/strong>19<\/em>, 7548-7556. Cover article<\/em>. [PDF]<\/a><\/p>\n\n\n\n

Laissue, P.P., Reiter, C., Hiesinger, P.R.<\/strong>, Halter, S., Fischbach, K.-F., and Stocker, R.F. (1999)<\/em>. Three-dimensional reconstruction of the antennal lobe in Drosophila melanogaster. J. Comp. Neurol<\/em>.<\/strong>405<\/em>, 543-552. [PDF]<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

All links open original lab publication PDF files in a new tab. For more info on the book ‘The Self-Assembling Brain’ visit selfassemblingbrain.com. 2026 Kehribar M, Wit CB, Krasikova K,…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"nf_dc_page":"","footnotes":""},"class_list":["post-26","page","type-page","status-publish","hentry"],"yoast_head":"\nPublications - Hiesinger Lab<\/title>\n<meta name=\"description\" content=\"Original papers and reviews by Robin Hiesinger and co-workers.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.flygen.org\/?page_id=26\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - Hiesinger Lab\" \/>\n<meta property=\"og:description\" content=\"Original papers and reviews by Robin Hiesinger and co-workers.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.flygen.org\/?page_id=26\" \/>\n<meta property=\"og:site_name\" content=\"Hiesinger Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-13T15:29:48+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"12 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/lab.flygen.org\\\/?page_id=26\",\"url\":\"https:\\\/\\\/lab.flygen.org\\\/?page_id=26\",\"name\":\"Publications - 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