{"id":2,"date":"2021-11-26T08:24:19","date_gmt":"2021-11-26T08:24:19","guid":{"rendered":"http:\/\/box2099\/cgi\/addon_GT.cgi?s=GT::WP::Install::EIG+%28flygenor%29+-+10.0.87.40+%5BWordpress%3b+\/var\/hp\/common\/lib\/Wordpress.pm%3b+543%3b+Hosting::gap_call%5D\/?page_id=2"},"modified":"2026-07-06T11:24:44","modified_gmt":"2026-07-06T11:24:44","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/lab.flygen.org\/?page_id=2","title":{"rendered":"Research"},"content":{"rendered":"\n

How are neural circuits ‘genetically encoded’ ?<\/em><\/h2>\n\n\n\n

The genome does not describe the wiring diagram, it contains information to grow the wiring diagram<\/strong>.<\/h4>\n\n\n\n

Neurogenetics is the study of the genes that shape neuronal development and function. The genetic approach implies that it is indeed genes, their regulation and their products, that give rise to the complexity of neuronal networks. How can a few thousand genes and their regulatory elements contain the information to grow a fly’s brain that is capable of a feat like computing safe flight in three dimensions? We want to understand how information is encoded in neural networks prior to learning<\/p>\n\n\n\n

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Our task is to try to understand genome-driven growth can encode information during brain development. Our favorite approach is live observation of the development of brain wiring – the self-assembly of the brain – using Drosophila <\/em>as a model, combined with computational modeling.<\/p>\n<\/blockquote>\n\n\n\n

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Projects Based on Active Grants<\/h2>\n\n\n\n
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\"\"<\/figure>\n<\/div><\/div>\n\n\n\n
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Synaptic Promiscuity in Brain Development<\/h4>\n\n\n\n

2021-2027<\/p>\n\n\n\n

see synpromiscuity.flygen.org<\/a> for more information<\/p>\n<\/div>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div><\/div>\n\n\n\n
\n

From Imprecision to Robustness in Neural Circuit Assembly<\/h4>\n\n\n\n

2022-2030<\/p>\n\n\n\n

see robustcircuit.flygen.org<\/a> for more information<\/p>\n<\/div>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div><\/div>\n\n\n\n
\n

Autophagic Regulation of Synapse Formation and Maintenance<\/h4>\n\n\n\n

2021-2029<\/p>\n\n\n\n

see syntophagy.de<\/a> for more information<\/p>\n<\/div>\n<\/div>\n\n\n\n

\n
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\"\"<\/figure>\n<\/div>\n\n\n\n
\n

A bio-inspired electrical engineering approach to circuit development – Insights from modeling growth of a Drosophila neural network<\/h4>\n\n\n\n

2025-2028<\/p>\n\n\n\n

Collaboration with the Karlheinz Ochs, Bochum<\/p>\n<\/div>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div>\n\n\n\n
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The Information Content of Brain Wiring<\/h4>\n\n\n\n

2026-2031<\/p>\n\n\n\n

See news <\/strong>page<\/a> for more information.<\/p>\n<\/div>\n<\/div>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

How are neural circuits ‘genetically encoded’ ? The genome does not describe the wiring diagram, it contains information to grow the wiring diagram. Neurogenetics is the study of the genes…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"nf_dc_page":"","footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"yoast_head":"\nResearch - Hiesinger Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.flygen.org\/?page_id=2\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Hiesinger Lab\" \/>\n<meta property=\"og:description\" content=\"How are neural circuits ‘genetically encoded’ ? 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