EGFR-dependent suppression of synaptic autophagy
is required for neuronal circuit development
Suchetana B. Dutta, Gerit Arne Linneweber, Maheva Andriatsilavo, Peter Robin Hiesinger*, Bassem A. Hassan*, * co-corresponding authors
In brief
Using the development of the fruit fly Drosophila melanogaster brain as a model system, Dutta et al. identify a critical developmental period during which coupling axon branching to synaptic degradation is required for neural circuit formation. This coupling relies on EGFR-dependent restriction of local synaptic degradation.
